Thrombus Removal With ClotTriever in the ClotTriever Outcomes Registry: The Effect of Thrombus Chronicity

In deep vein thrombosis (DVT), the composition of thrombus transforms over time, becoming more resistant to anticoagulation and thrombolytic treatment. A patient's clinical symptoms are often used estimate help determine effective However, DVT can be asymptomatic for days weeks. Using data from CLOUT (ClotTriever Outcomes) Registry, a study evaluating real-world patient outcomes after treatment lower extremity (LE) with ClotTriever System (Inari Medical, Irvine, Calif), we compared indicators chronicity examined their effects on removal. The Registry is actively enrolling ≤500 proximal LE patients. Thrombus was assessed before procedure according symptom duration, during pretreatment imaging findings (venography, intravascular ultrasound, duplex ultrasound) history, thrombectomy by visual inspection morphology. classified as acute (<2 weeks), subacute (2-6 or chronic (>6 weeks). Complete near-complete removal defined ≥75%, calculated via core laboratory-adjudicated Marder scores. total 225 patients (age, 58.7 ± 15.3 years; 52.9% male) 240 treated limbs were included in our interim analysis. Overall, 93 (41.5%) had contraindications agents 53 (23.6%) prior DVT. median time 28.0 minutes (range, 20.0-45.0 minutes). Classified 69.1% thrombus, 22.2% 8.7% thrombus. After imaging, reclassified 38.1% acute, 37.7% subacute, 24.2% chronic. thrombectomy, further 30.5% 36.1% 33.5% Comparing initial final post-thrombectomy assessment, 55.6% been misclassified, most having than expected (Fig). With addition classification has improved. still 16.5% expected. similar across classifications: 86.2% 78.1% 81.7% an all-comer population, that first using duration found nearly one half limbs. use device removing each category. This finding implications choice presenting